A Network-Based Approach to Cell Metabolism: From Structure by Oriol Güell

By Oriol Güell

This thesis makes use of a systems-level method of learn the mobile metabolism, unveiling new mechanisms and responses that have been most unlikely to arrive with conventional reductionists approaches.

The effects suggested right here have a possible software in parts like metabolic engineering and disorder therapy. they can even be utilized in identifying the accuracy of the gene essentiality of latest genome-scale reconstructions.

Different equipment and strategies, in the contexts of structures Biology and the sphere often called advanced Networks research were utilized during this paintings to teach varied gains of the robustness of metabolic networks. the categorical concerns addressed right here diversity from natural topological aspec

ts of the networks themselves to the stability of biochemical fluxes.


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